Zipline cofounder and CTO Keenan Wyrobek built an autonomous drone logistics network that started delivering blood and medicine across Rwanda and has since scaled to doorstep package delivery in the US, handling payloads up to 8 pounds.

The technical and regulatory path from African medical supply chains to suburban last-mile delivery is not obvious, and Wyrobek goes deep on exactly how Zipline solved both. The engineering decisions, the airspace negotiations, the hardware tradeoffs: this interview covers the specific mechanics, not the press release version.

If you care about autonomous systems, real-world robotics deployment, or how hard infrastructure problems actually get solved at scale, this conversation with Wyrobek is worth the full runtime.

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